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Amphiphysin Mouse, Unlabeled, Clone: 15, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610714

Catalog No. BDB610714


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Description

Description

Amphiphysin was originally described in chicken brain and located at the presynaptic terminal. It was also identified as the major autoantigen in Stiff-Man Syndrome (SMS), a neurological disease linked to an autoimmune response to antigens in the central nervous system. Amphiphysin interacts with several proteins important in the synaptic vesicle cycle. Amphiphysin contains a Src homology 3 (SH3) domain that binds to the C-terminal and proline-rich region of dynamin at the synapse. Microinjection of amphiphysin inhibits synaptic vesicle endocytosis. In addition, amphiphysin binds to AP-2 at the plasma membrane and to the inositol 5-phosphatase, synaptojanin. The interaction between synaptojanin and amphiphysin also appears to be mediated through amphiphysin's SH3-domain.

Specifications

Specifications

Amphiphysin
15
Unconjugated
Affinity Purified
Human Amphiphysin aa. 258-414
50μg
Cell Biology
Primary
Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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