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AMPK beta-2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA513792

Catalog No. PIPA513792

Item Discontinued This item has been discontinued by the supplier and is no longer available. Please reach out to your sales representative.


Description

Description

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

AMPK beta-2
Polyclonal
PRKAB2
5′-AMP-activated protein kinase, beta-2 subunit, AMPK beta-2 chain
Rabbit
Antigen affinity chromatography
RUO
108097, 5565
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
Unconjugated
O43741, Q6PAM0
PRKAB2
KLH conjugated synthetic peptide between 3-33 amino acids from the N-terminal region of human AMPK beta2 (PRKAB2)
400 μL
Primary
Human, Mouse
Antibody
IgG
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