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AMPK gamma-1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527471

Catalog No. PIPA527471


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Description

Description

PA5-27471 targets AMPK gamma 1 in IP and WB applications and shows reactivity with Human and mouse samples. The PA5-27471 immunogen is recombit fragment corresponding to a region within amino acids 1 and 224 of Human AMPK gamma 1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Specifications

Specifications

AMPK gamma-1
Polyclonal
Unconjugated
PRKAG1
Liquid
PRKAG1
Recombit fragment corresponding to a region within amino acids 1 and 224 of Human AMPK gamma 1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunoprecipitation, Western Blot
0.33 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
P54619, O54950
AMPKG, 5′-AMP-activated protein kinase subunit gamma-1, 5′-AMP-activated protein kinase, gamma-1 subunit, AMPK gamma-1 chain, AMPK gamma1
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
19082, 5571
Documents
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