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Amyloid Precursor Protein Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA184165

Catalog No. PA184165


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Description

Description

PA1-84165 recognizes both intact APP and also the C99 fragment generated by Beta-secretase. The sequence recognized by this antibody corresponds to amino acids 85-99 of the C99 fragment. Heat-mediated antigen retrieval is recommended for the staining of paraffin sections.

Amyloid Precursor Protein (APP) or Amyloid beta protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1; APP is rapidly internalized via clathrin-coated pits. APP is important for neurite growth, neuronal adhesion and axonogenesis. Mutations in the APP gene can lead to Alzheimer disease 1 (AD1). This anitbody recognizes APP (b-APP770) with a MW of approximately 100kDa.
Specifications

Specifications

Amyloid Precursor Protein
Polyclonal
Unconjugated
APP
Liquid
APP
Synthetic peptide corresponding to residues 737-751 of human APP.
Affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry (Paraffin), Western Blot
1.0 mg/mL
PBS with 0.02% sodium azide; pH 7.4
P05067, P12023, P08592
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2, Pan-Abeta
Rabbit
IgG
100 μg
4°C or -20°C if preferred
Primary
11820, 351, 54226
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