Androgen Receptor Goat anti-Human, Polyclonal, Invitrogen™
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA19005
This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy′s disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).
|Synthetic peptide corresponding to the N terminus amino acids EVQLGLGRVYPRPPSC.|
|Antigen affinity chromatography|
|ChIP assay, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|AR; KD; AIS; TFM; DHTR; SBMA; NR3C4; SMAX1; HUMARA; androgen receptor (dihydrotestosterone receptor testicular feminization spinal and bulbar muscular|
|-20° C, Avoid Freeze/Thaw Cycles|
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