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MilliporeSigma™ anti-Angiogenin, Polyclonal

Goat Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC317L100UG

Catalog No. PC317L100UG

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Specifically detects Angiogenin Clone: in Human samples, and it is validated for ELISA, Neutralization, Immuno Blotting

Angiogenin was initially isolated from culture medium conditioned by human colon adenocarcinoma cells (HT-29 cells) as a~14kDa protein homologous to pancreatic ribonuclease A. Angiogenin is a potent inducer of blood vessel formation whose enzymatic and three-dimensional relationship to RNAse A is critical for its biological function. It exerts ribonucleolytic activity that is several magnitudes lower than that of RNAse A but nonetheless essential for angiogenesis since inhibition of RNAse activity will also abolish angiogenesis. Internalization and translocation to the nucleolus are also required for activity. Angiogenin binds to high affinity endothelial cell receptors and with lower affinity to extracellular matrix components. An angiogenin binding protein (~42kDa) previously isolated from the cell surfaces of endothelial cells has been shown to be a member of the actin family by peptide mapping and partial amino acid sequencing. It has also been shown in vitro that angiogenin absorbed on plastic will support the cell adhesion of both endothelial cells and fibroblasts. Angiogenin is differentially produced by anchorage-dependent growing cells including vascular endothelial cells, aortic smooth muscle cells, fibroblasts and tumor cells.
Specifications

Specifications

Angiogenin
Unconjugated
purified
human angiogenin
100μg
−20°C
Polyclonal
Human
ELISA, Immuno Blotting, Immunoblot, Neutralization
Lyophilized from 20mM ammonium bicarbonate, PBS, 100μg FAF-BSA.
Goat
IgG
RUO
Primary
Recognizes angiogenin. Antibody Target Gene Symbol: ANG Target Synonym: AI385586, ALS9, Ang1, Ang2, ANGIOGENIN, ANGIOGENIN 2, BRB, BRN, HEL168, MGC140149, MGC22466, MGC71966, RNASE4, RNASE5, Rnase5a Entrez Gene Name: angiogenin, ribonuclease, RNase A family, 5
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