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Annexin II (Lipocortin II, Calpactin I) Mouse anti-Human, FITC, Clone: 5, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611838

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Catalog No. BDB611838


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Description

Description

Annexin II (p36), originally discovered as a substrate for the src oncogene, is one of the most studied members of the annexin family of calcium-dependent phospholipid-binding proteins. It exists in cells as either a monomer or a heterotetramer complexed with p11, an S100-related protein. In vitro, it has been found that unphosphorylated annexin II is capable of causing aggregation of chromaffin granules, and, upon phosphorylation, induces fusion of the granules' membranes. A similiar phenomenon may occur in the final steps of exocytosis after cytoplasmic annexin translocates to the subplasmalemmal region and is phosphorylated by protein kinase C. However, other studies refute annexin II's involvement in exocytosis, and a conclusive role for annexin II in membrane trafficking remains debated.

Host Species: Mouse
Clone: 5
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human Annein II aa. 123-328

Immunofluorescence, Immunoprecipitation

Specifications

Specifications

Annexin II (Lipocortin II, Calpactin I)
5
FITC
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Immunofluorescence
250μg/mL
Lipocortin II, Calpactin I
Affinity Purified
Human Annein II aa. 123-328
50μg
Cell Biology
Primary
Human
Documents
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