Annexin II (Lipocortin II, Calpactin I) Mouse anti-Human, FITC, Clone: 5, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611839
Annexin II (p36), originally discovered as a substrate for the src oncogene, is one of the most studied members of the annexin family of calcium-dependent phospholipid-binding proteins. It exists in cells as either a monomer or a heterotetramer complexed with p11, an S100-related protein. In vitro, it has been found that unphosphorylated annexin II is capable of causing aggregation of chromaffin granules, and, upon phosphorylation, induces fusion of the granules' membranes. A similiar phenomenon may occur in the final steps of exocytosis after cytoplasmic annexin translocates to the subplasmalemmal region and is phosphorylated by protein kinase C. However, other studies refute annexin II's involvement in exocytosis, and a conclusive role for annexin II in membrane trafficking remains debated.
Host Species: Mouse
Species Reactivity [for Features Main]: Human
Immunogen: Human Annein II aa. 123-328
|Annexin II (Lipocortin II, Calpactin I)|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|Lipocortin II, Calpactin I|
|Human Annein II aa. 123-328|
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