Anthrax Lethal Factor Rabbit anti-Bacteria, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141171
Anthrax PA (Protective Antigen) and Anthrax LF (Lethal Factor), along with Anthrax EF (Edema Factor), are toxins produced by Bacillus anthracis. All three of the proteins must be present for toxic entry into cells. PA is secreted from Bacillus anthracis as an 83kDa (PA83) protein which is cleaved by furin protease, releasing a 20kDa fragment. The 63kDa portion (PA63) of the cleavage product forms a heptamer, which binds the toxins LF and EF. This complex enters via receptor-mediated endocytosis where LF and EF exert their toxic effects.Suggested positive control: recombinant protein.
|Anthrax Lethal Factor|
|whole serum diluted in PBS with 0.2% gelatin and 0.05% sodium azide|
|Synthetic peptide corresponding ot residues 47-65 of Anthrax lethal factor.|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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