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AP2M1 Chicken anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Chicken Polyclonal Antibody

Manufacturer:  Invitrogen PA520745

Catalog No. PIPA520745


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Description

Description

A suggested positive control is human kidney tissue lysate. PA5-20745 can be used with blocking peptide PEP-0859.

The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.
Specifications

Specifications

AP2M1
Polyclonal
Unconjugated
AP2M1
Liquid
AP2M1
A 16 amino acid peptide near the carboxy terminus of human AP2M1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q96CW1, P84091, P84092
AP50, CLAPM1, mu2; AP-2 complex subunit mu; AP-2 mu 2 chain; AP-2 mu chain; HA2 50 kDA subunit; adapter-related protein complex 2 mu subunit; adaptin-mu2; adaptor protein complex AP-2 subunit mu; clathrin adaptor complex AP2, mu subunit; clathrin assembly protein complex 2 medium chain; clathrin coat adaptor protein AP50; clathrin coat assembly protein AP50; clathrin coat-associated protein AP50; clathrin-associated/assembly/adaptor protein, medium 1; plasma membrane adaptor AP-2 50 kDa protein;
Chicken
IgY
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
116563, 1173, 11773
Documents
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