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AP50 Mouse, Unlabeled, Clone: 31, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611351

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Catalog No. BDB611351


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Description

Description

Sorting of integral membrane proteins is mediated vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (γ, α, δ, ε, and β1, β2, β3, β4 respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, µ4 respectively) and one small chain ( σ1, σ2, σ3, σ4 respectively). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2, µ2 (AP50) interacts with integral membrane proteins via binding to tyrosine-based signals with the canonical motif YXXφ. In addition, AP50/µ2 is required for both the assembly and the proton transport activity of vacuolar (H+)-ATPases in clathrin coated vesicles. Thus, AP50/µ2 may be involved in targeting integral membrane proteins that are sorted based on tyrosine-based signals and involved in assembly of functional ion channels associated with clathrin coated vesicles.

Host Species: Mouse
Clone: 31
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse AP50/µ2 aa. 110-230
Formula Weight [Chemical]: 50kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

AP50
31
Unconjugated
Affinity Purified
Mouse AP50/μ2 aa. 110-230
150μg
Cell Biology
Primary
Human, Murine, Rat
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
SDS
Documents
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