Protein APC Rabbit anti-Human, Mouse, Xenopus laevis, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA137093
This antibody is predicted to react with amphibian, mouse, porcine and rat based on sequence homology. Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is normal colon or colon carcinoma.This gene encodes a tumor suppressor protein that includes among its many intracellular functions one of nuclear export. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal domit pre-maligt disease that usually progresses to maligcy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
|PBS with 1% BSA and <0.1% sodium azide; pH 7.6|
|Adenomatous Polyposis Coli, APC, DP2, DP2.5, DP3, FAP, FPC, GS|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Synthetic peptide from C-terminus of human APC protein|
|Antigen affinity chromatography|
|Human, Mouse, Xenopus laevis|
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