Cdc27 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520942
A suggested positive control is mouse liver tissue lysate. PA5-20942 can be used with blocking peptide PEP-1056.Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC3, also known as CDC27, a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), is a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. APC3 contains a tetratricopeptide repeat (TPR) region and interacts with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1.
|A 19 amino acid peptide near the carboxy terminus of human APC3.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|P30260, A2A6Q5, Q4V8A2|
|ANAPC3, APC3, CDC27Hs, D0S1430E, D17S978E, HNUC, NUC2; CDC27 homolog; H-NUC; anaphase promoting complex subunit 3; anaphase-promoting complex subunit 3; anaphase-promoting complex, protein 3; cell division cycle protein 27 homolog; nuc2 homolog|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|217232, 360643, 996|
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