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APC6 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520947

Catalog No. PIPA520947


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Description

Description

A suggested positive control is human liver tissue lysate. PA5-20947 can be used with blocking peptide PEP-1061.

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC6 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC6, it has been shown to interact with and is stabilized by CDC26 through an intermolecular TPR mimic composed of one helix from each protein.
Specifications

Specifications

APC6
Polyclonal
Unconjugated
CDC16
Liquid
CDC16
An 18 amino acid peptide near the amino terminus of human APC6.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q13042, Q8R349
RP11-569D9.4, ANAPC6, APC6, CUT9; CDC16Hs; anaphase-promoting complex subunit 6; anaphase-promoting complex, subunit 6; cell division cycle protein 16 homolog; cyclosome subunit 6
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
69957, 8881
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