APC6 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520947
A suggested positive control is human liver tissue lysate. PA5-20947 can be used with blocking peptide PEP-1061.Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC6 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC6, it has been shown to interact with and is stabilized by CDC26 through an intermolecular TPR mimic composed of one helix from each protein.
|An 18 amino acid peptide near the amino terminus of human APC6.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|RP11-569D9.4, ANAPC6, APC6, CUT9; CDC16Hs; anaphase-promoting complex subunit 6; anaphase-promoting complex, subunit 6; cell division cycle protein 16 homolog; cyclosome subunit 6|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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