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Cdc23 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520949

Catalog No. PIPA520949


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Description

Description

A suggested positive control is K562 cell lysate. PA5-20949 can be used with blocking peptide PEP-1063.

Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC8 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.
Specifications

Specifications

Cdc23
Polyclonal
Unconjugated
CDC23
Liquid
CDC23
A 17 amino acid peptide near the center of human APC8.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9UJX2, Q8BGZ4
ANAPC8, APC8, CUT23; anaphase promoting complex subunit 8; anaphase-promoting complex subunit 8; cell division cycle protein 23 homolog; cyclosome subunit 8
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
291689, 52563, 8697
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