APE1 Goat anti-Human, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA19007
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.This antibody is predicted to react with bovine, canine and porcine based on sequence homology.
|Synthetic peptide corresponding to the N terminus amino acids PKRGKKGAVAEDGD.|
|Antigen affinity chromatography|
|Immunohistochemistry, Immunohistochemistry (Paraffin), peptide-ELISA, Western Blot|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|APEX; APEX1; APEX nuclease (multifunctional DNA repair enzyme); APE; APX; APE1; APEN; HAP1; REF1; REF-1; AP lyase; AP endonuclease class I; apurinic/a|
|-20° C, Avoid Freeze/Thaw Cycles|
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