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ATG7 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520174

Catalog No. PIPA520174


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Description

Description

A suggested positive control is L1210 cell lysate. PA5-20174 can be used with blocking peptide PEP-0291.

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog. In mammalian cells, APG7 is essential for autophagy conjugation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles. It has been suggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death.
Specifications

Specifications

ATG7
Polyclonal
Unconjugated
ATG7
Liquid
ATG7
A 17 amino acid peptide from near the amino terminus of human APG7.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O95352, Q9D906
APG7-LIKE, APG7L, GSA7; ATG12-activating enzyme E1 ATG7; autophagy-related protein 7; hAGP7; ubiquitin activating enzyme E1-like protein; ubiquitin-activating enzyme E1-like protein; ubiquitin-like modifier-activating enzyme ATG7
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
10533, 74244
Documents
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