ATG7 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523360
DescriptionAutophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important for normal growth control and may be defective in tumor cells. A member of the autophagy family of proteins is APG7L which was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog. In mammalian cells, APG7L is essential for autophagy conjugation systems, autophagosome formation, and starvation-induced bulk degradation of proteins and organelles. The protein thus plays an indispensable role in the initial step of the conjugation system. APG7L interacts with Apg8p/Aut7p and Aut1p/Apg3p in addition to Apg12p. The protein maps to the 3p25.3-p25.2 region of the human chromosome. Ablation of the protein leads to abnormal swellings and dystrophy of purkinje cell axon terminals in the deep cerebellar nuclei.
|Synthetic peptide (554 NDVVAPGDSTRDRTLDQQC 572) of APG7L protein.|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|APG7-LIKE, APG7L, GSA7, ATG12-activating enzyme E1 ATG7, autophagy-related protein 7, hAGP7, ubiquitin activating enzyme E1-like protein, ubiquitin-activating enzyme E1-like protein, ubiquitin-like modifier-activating enzyme ATG7|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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