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Aralar Mouse anti-Human, Unlabeled, Clone: 8, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611162

Catalog No. BDB611162

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Mitochondria are the primary sites of ATP production within the cell. They contain two different membranes, the outer membrane and the inner membrane. The outer membrane contains porins which form pores in the membrane and render it highly permeable. The inner membrane is less permeable and contains a high protein-to-lipid ratio. This membrane contains a number of carrier proteins that mediate metabolite transport. These belong to a superfamily of related proteins that are found in S. cerevisiae, C. elegans, and several mammalian
species. Aralar, a human member of this family, is expressed in the mitochondria within heart, skeletal muscle, and brain. Its C-terminal half resembles proteins of the mitochondrial solute carrier superfamily and its N-terminal portion contains four putative Ca2+;-binding EF-hand domains. The presence of the EF-hands in Aralar make it a close relative of the large family of Ca2+;-binding proteins that includes calmodulin and myosin light chain. Aralar is thought to function as a Ca2+;-regulated mitochondrial anion carrier or as a Ca2+; and anion cotransporter since it is expressed primarily in tissues where cell function relies heavily on Ca2+;- signaling.

Host Species: Mouse
Clone: 8
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Aralar aa. 1-119
Formula Weight [Chemical]: 70kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

Aralar
8
Unconjugated
Murine
IgG1
RUO
Primary
Human
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Human Aralar aa. 1-119
50μg
Cell Biology
Monoclonal
Documents
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