Aralar Mouse anti-Human, Unlabeled, Clone: 8, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611162
Mitochondria are the primary sites of ATP production within the cell. They contain two different membranes, the outer membrane and the inner membrane. The outer membrane contains porins which form pores in the membrane and render it highly permeable. The inner membrane is less permeable and contains a high protein-to-lipid ratio. This membrane contains a number of carrier proteins that mediate metabolite transport. These belong to a superfamily of related proteins that are found in S. cerevisiae, C. elegans, and several mammalian
species. Aralar, a human member of this family, is expressed in the mitochondria within heart, skeletal muscle, and brain. Its C-terminal half resembles proteins of the mitochondrial solute carrier superfamily and its N-terminal portion contains four putative Ca2+;-binding EF-hand domains. The presence of the EF-hands in Aralar make it a close relative of the large family of Ca2+;-binding proteins that includes calmodulin and myosin light chain. Aralar is thought to function as a Ca2+;-regulated mitochondrial anion carrier or as a Ca2+; and anion cotransporter since it is expressed primarily in tissues where cell function relies heavily on Ca2+;- signaling.
Host Species: Mouse
Species Reactivity: Human
Immunogen: Human Aralar aa. 1-119
Formula Weight [Chemical]: 70kDa
Immunofluorescence, Western Blotting
|Immunofluorescence, Western Blot|
|Human Aralar aa. 1-119|
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