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ARAP2 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523336

Catalog No. PIPA523336


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Description

Description

ARAP2, also known as Centaurin-delta-1, is a protein with ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. A phosphatidylinositol-3,4,5-trisphosphate-dependent GTPase-activating protein, ARAP2 binds to RhoA-GTP, but lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. It modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Usually ARAP2 is activated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and can be activated by phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. ARAP2 associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. It is usually detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. 
Specifications

Specifications

ARAP2
Polyclonal
whole serum with 50% glycerol and 0.025% sodium azide
Q8WZ64
CENTD1, PARX, Arf and Rho GAP adapter protein 2, arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2, centaurin, delta 1, centaurin-delta-1, cnt-d1
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Non-human Primate
Immunohistochemistry (Paraffin)
Unconjugated
ARAP2
Liquid
ARAP2
Synthetic peptide (78 ANVHKTKKNDDPSKDY 93) of ARAP2 protein.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
116984
Documents
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