ARAP2 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523336
DescriptionARAP2, also known as Centaurin-delta-1, is a protein with ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. A phosphatidylinositol-3,4,5-trisphosphate-dependent GTPase-activating protein, ARAP2 binds to RhoA-GTP, but lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. It modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Usually ARAP2 is activated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and can be activated by phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. ARAP2 associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. It is usually detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
|whole serum with 50% glycerol and 0.025% sodium azide|
|CENTD1, PARX, Arf and Rho GAP adapter protein 2, arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2, centaurin, delta 1, centaurin-delta-1, cnt-d1|
|Human, Non-human Primate|
|Synthetic peptide (78 ANVHKTKKNDDPSKDY 93) of ARAP2 protein.|
|-20° C, Avoid Freeze/Thaw Cycles|
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