Arc Mouse, Unlabeled, Clone: 40, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 612602
Immediate early genes (IEGs) are the first to be transcribed upon cellular stimulation. Two groups of these genes have been characterized: those which encode transcription factors that indirectly influence cellular activity, and those which encode effector proteins that directly affect cellular activity. Arc (Activity-Regulated Cytoskeleton-associated protein) encodes an effector protein associated with the actin cytoskeletal matrix. In activated neurons of the hippocampus, Arc gene expression is rapidly induced. Arc protein is concentrated in the actin cortex,
adjacent to the plasma membrane of the cell body and dendrites. Arc has a putative role in the maintenance of neuronal plasticity and in activity-dependent changes in dendrite function. Cocaine and D2 receptor antagonists are known to trigger the production and localization of Arc to dendrites and neuronal cell bodies.
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|Activity-Regulated Cytoskeleton-associated protein|
|Rat Arc aa. 264-385|
|Human, Murine, Rat|
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