ARC Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA130681
PA1-30681 detects ARC from human samples. PA1-30681 has been successfully used in Western blot applications. Suggested positive control is Hela whole cell lysate. The PA1-30681 immunogen is synthetic peptide, corresponding to amino acids 191-208 of Human ARC. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms. Isoform 1 is involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. ARC inhibits extrinsic apoptotic pathways two different ways. The first is by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. The second way is by interacting with CASP8 in a mitochondria localization-and phosphorylation-dependent manner, which in turn limits the amount of soluble CASP8 avaliable for DISC-mediated activation. ARC also inhibits intrinsic apoptotic pathways in response to a wide range of stresses through interactions with BAX. This results in BAX inactivation and prevents mitochondrial dysfunction and release of pro-apoptotic factors. Mutations affecting the gene can results in myoclonus, familiam cortical.
|Synthetic peptide, corresponding to amino acids 191-208 of Human ARC.|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.02% sodium azide|
|Apoptosis Repressor with CARD, Nop30, Nucleolar protein of 30 kDa, Nucleolar protein 3, Muscle-enriched cytoplasmic protein, Myp|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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