ARF-3 Mouse, Unlabeled, Clone: 41, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610784
The ADP-ribosylation factors (ARFs) belong to the multigene family of small GTPases capable of activating cholera toxin. ARFs fall into three different classes: Class I is composed of ARF-1, ARF-2, and ARF-3; Class II consists of ARF-4 and ARF-5; and Class III includes ARF6. Unique to ARFs is their lack of intrinsic GTP hydrolysis activity, a high affinity for GDP in a Mg2+-dependent manner, and phospholipid requirement for nucleotide exchange. ARFs are involved in intravesicular acidification of microsomal vesicles, endosome fusion, nuclear membrane assembly, and formation of clathrin-coated vesicles. In addition, GTP and ARF-3 are required for the activation of phospholipase D (PLD), an early cellular response triggered by the binding of receptors on the cell surface in response to numerous extracellular signals. Although predominantly cytosolic, ARF-3 can be translocated to cellular membranes upon cellular stimulation. The transition between the GDP-bound ARF-3 to the GTP-ARF-3 is facilitated by a high molecular weight guanine nucleotide-exchange factor sensitive to brefeldin. ARF-3 has been reported to be the most abundant in brain, kidney, and liver.
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
|ADP Ribosylation Factor-3|
|Human ARF3 aa. 1-181|
|Canine, Chicken, Frog, Human, Murine, Rat|
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