ARHGAP20 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523204
DescriptionARHGAP20 is a potent GTPase-activating protein (GAP) and convert Rho-type GTPases into an inactive GDP-bound state. It contains a pleckstrin homology (PH) domain, a Ras-associating domain, a Rho-GAP domain and two Annexin-like (ANXL) repeats. ARHGAP20 is a direct downstream target of Rap1 in the neurite outgrowth while it’s over expression leads to inactivation of Rho for promoting the neurite outgrowth in a Rap1-dependent manner. ARHGAP20 is a tumor suppressor gene and is inactivated by deletion in breast cancer and also by chromosomal translocation in B-cell chronic lymphocytic leukemia. Reports suggest that it may take part in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis. It is expressed predomitly in human brain, liver, ovary and spinal cord while low expression is found in lymph nodes and fetal liver.
|Synthetic peptide (587 SLKNWSLKKKAKAARP 602) of ARHGAP20/Rho GTPase activating protein 20 protein.|
|Human, Non-human primate|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.2% gelatin and 0.05% sodium azide|
|RARHOGAP, RA and RhoGAP domain containing protein, rho GTPase-activating protein 20, rho-type GTPase-activating protein 20|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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