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ARHGAP20 Rabbit anti-Human, Non-human primate, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523204

Catalog No. PIPA523204


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Description

Description

ARHGAP20 is a potent GTPase-activating protein (GAP) and convert Rho-type GTPases into an inactive GDP-bound state. It contains a pleckstrin homology (PH) domain, a Ras-associating domain, a Rho-GAP domain and two Annexin-like (ANXL) repeats. ARHGAP20 is a direct downstream target of Rap1 in the neurite outgrowth while it’s over expression leads to inactivation of Rho for promoting the neurite outgrowth in a Rap1-dependent manner. ARHGAP20 is a tumor suppressor gene and is inactivated by deletion in breast cancer and also by chromosomal translocation in B-cell chronic lymphocytic leukemia. Reports suggest that it may take part in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis. It is expressed predomitly in human brain, liver, ovary and spinal cord while low expression is found in lymph nodes and fetal liver.
Specifications

Specifications

ARHGAP20
Polyclonal
Unconjugated
ARHGAP20
Liquid
ARHGAP20
Synthetic peptide (587 SLKNWSLKKKAKAARP 602) of ARHGAP20/Rho GTPase activating protein 20 protein.
Protein G
RUO
Antibody
Polyclonal
Human, Non-human primate
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q9P2F6
RARHOGAP, RA and RhoGAP domain containing protein, rho GTPase-activating protein 20, rho-type GTPase-activating protein 20
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
57569
Documents
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