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beta-Arrestin 2 Rabbit anti-Bovine, Canine, Equine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523296

Catalog No. PIPA523296


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Description

Description

Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors.  ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.
Specifications

Specifications

beta-Arrestin 2
Polyclonal
Unconjugated
ARRB2
Liquid
ARRB2
Synthetic peptide (LGKRDFVDHLDKVDPVDG (aa23-40)) of ARRB2 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Canine, Equine, Human, Mouse, Non-human primate, Rat
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
P32120, P32121, Q91YI4, P29067
ARB2, ARR2, BARR2, arrestin 3, arrestin beta-2, beta-arrestin-2
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
100072892, 216869, 25388, 281638, 409, 607262
Documents
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