ASGR1 Mouse anti-Human, Rat, Clone: 8D7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA140244
MA1-40244 detects ASGPR from rat and human samples. MA1-40244 has been successfully used in ELISA, flow cytometry, immunohistochemistry (frozen), immunofluorescence, and Western blot applications. The typical starting working dilution is 1:10. The MA1-40244 immunogen is crude rat liver membrane extracts. Positive control: Rat hepatocytes; Negative control: Rat kidney, pancreas, small intestine, colon.The asialoglycooprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) which mediates binding, internalisation and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner, i.e. it is present on the sinusoidal and lateral palasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediate the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed.The rat asialoglycoprotein receptor (ASGPR) consists of three polypeptide subunits: rat hepatic lectin (RHL)-1, RHL-2 and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.
|PBS with 0.1% BSA and 0.02% sodium azide|
|ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot|
|Crude rat liver membrane extracts|
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