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ASGR1 Mouse anti-Human, Rat, Clone: 8D7, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA140244

Catalog No. 01-676-577



Description

Description

MA1-40244 detects ASGPR from rat and human samples. MA1-40244 has been successfully used in ELISA, flow cytometry, immunohistochemistry (frozen), immunofluorescence, and Western blot applications. The typical starting working dilution is 1:10. The MA1-40244 immunogen is crude rat liver membrane extracts. Positive control: Rat hepatocytes Negative control: Rat kidney, pancreas, small intestine, colon

The asialoglycooprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) which mediates binding, internalisation and degradation of extracellular glycoproteins that have exposed terminal galactose residues. The receptor is expressed on the surface of the hepatocytes in a polar manner, i.e. it is present on the sinusoidal and lateral palasma membranes but not on the bile canalicular membrane. The mammalian hepatic ASGPR mediate the endocytosis and degradation of serum proteins from which terminal sialic residues have been removed.The rat asialoglycoprotein receptor (ASGPR) consists of three polypeptide subunits: rat hepatic lectin (RHL)-1, RHL-2 and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 of rat ASGPR. The monoclonal antibody 8D7 is cross reactive with human ASGPR.
Specifications

Specifications

ASGR1
Monoclonal
0.1 mg/mL
PBS with 0.1% BSA and 0.02% sodium azide
P07306, P02706
ASGR1
Mouse
IgG1
100 μg
4° C
Primary
24210, 432
ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
8D7
Unconjugated
ASGR1
Liquid
ASGR1
Crude rat liver membrane extracts
Purified
RUO
Antibody
Monoclonal
Human, Rat
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