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Ataxin 3 Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Supplier: Thermo Scientific PA512088
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DescriptionMachado-Joseph disease is an autosomal domit neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.
|Ataxin-3; Machado-Joseph disease protein 1; Spinocerebellar ataxia type 3 protein ; ATXN3; ATX3; MJD; MJD1; SCA3|
|Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|-20° C, Avoid Freeze/Thaw Cycles|
|KLH conjugated synthetic peptide between 29-59 amino acids from the N-terminal region of human Ataxin3 (MJD)|
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