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ATG10 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520454

Catalog No. PIPA520454


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Description

Description

A suggested positive control is SK-N-SH cell lysate. PA5-20454 can be used with blocking peptide PEP-0571.

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy protein family is ATG10, an E2-like enzyme involved in two ubiquitin-like modifications essential for autophagosome formation: ATG12-ATG5 conjugation and the modification of a soluble form of MAP-LC3, a homolog of yeast Apg8, to a membrane-bound form. ATG10 has also been shown to interact with ATG12 in human embryonic kidney cells in the presence of ATG7. Multiple isoforms of ATG10 are known to exist.
Specifications

Specifications

ATG10
Polyclonal
Unconjugated
ATG10
Liquid
ATG10
A 15 amino acid peptide from near the carboxy terminus of human ATG10.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9H0Y0, Q8R1P4
PP12616, APG10, APG10L, pp12616; autophagy-related protein 10; ubiquitin-like-conjugating enzyme ATG10
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
66795, 688555, 83734
Documents
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