ATG16L1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA146475
Suggested positive control: NIH-3T3 whole cell lysates.Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is essential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane.
|Synthetic peptide corresponding to residues 1-100 of mouse ATG16L1. [Swiss-ProtNo. Q8C0J2]|
|Antigen affinity chromatography|
|PBS with 30% glycerol and 0.1% sodium azide|
|apg16l beta , apg16 autophagy 16like s cerevisiae , wdr30 , wd repeat domain 30 , atg16l anti|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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