ATG4B Rabbit anti-Human, Invitrogen
Rabbit Recombinant Polyclonal Antibody
Manufacturer: Invitrogen 710915
This antibody is predicted to react with monkey, mouse, rat, guinea pig and bovine based on sequence homology. Recombit rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombit monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombit antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombit rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.Cysteine protease ATG4B is an enzyme which is coded by ATG4B gene. Autophagy is a critical cellular homeostatic process that controls the turnover of damaged organelles and protein. ATG4B is a deubiquitin-like protease that plays dual roles in the core machinery of autophagy. ATG4B, cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. ATG4B is mainly expressed in the skeletal muscle, brain, heart, liver and pancreas.
|PBS with 0.09% sodium azide|
|AUTL1, APG4 autophagy 4 homolog B, AUT-like 1 cysteine endopeptidase, autophagin-1, autophagy-related cysteine endopeptidase 1, autophagy-related protein 4 homolog B, cysteine protease ATG4B, hAPG4B|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|full-length protein corresponding to Human ATG4b|
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