ATGL Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA116974
Suggested positive control: human adipose tissue lysates and mouse 3T3-L1 cell lysates, antigen standard for PNPLA2 (transient overexpression lysate).Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.
|Synthetic peptide corresponding to residues 400-500 of human ATGL.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|tris glycine with 150mM NaCl and 0.05% sodium azide|
|Adipose triglyceride lipase antibody, transport secretion protein (TTS) antibody, desnutrin, calcium-independent phospholipase A2z (iPL-A2z) antibody,|
|-20° C, Avoid Freeze/Thaw Cycles|
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