MilliporeSigma anti-ATM (Ab-3) (819-844), Polyclonal
Rabbit Polyclonal Antibody
Manufacturer: MilliporeSigma PC116100UG
Specifically detects ATM (819-844) Clone: in Human samples, and it is validated for ImmunoprecipitationAtaxia telangiectasia (AT) is an autosomal recessive disease characterized by cerebellar degeneration, an uneven gait (ataxia), neuromotor deterioration, the appearance of dilated blood vessels (telangiectasia) in the conjunctiva of the eyes and skin, and a large increase in cancer susceptibility. Cells of AT patients have increased sensitivity to ionizing radiation, defects in G1 and G2 of the cell cycle, and are unable to effect a normal p53-dependent G1 arrest due to failure to properly induce WAF1. Identification of the gene in AT patients showed that the disease is caused by a mutation of a single gene called ATM. Cloning of the ATM cDNA indicates that it contains a large open reading frame and encodes a putative protein of 3056 amino acids. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). A family of ATM-related genes has been identifed suggesting a role for these proteins in signal transduction and cell cycle regulation. ATM may be a key regulator of p53-mediated apoptosis.
|a synthetic peptide (CKSLASFIKKPFDRGEVESMEDDTNG) corresponding to amino acids 819-844 of human ATM|
|2°C to 8°C|
|In 50mM sodium phosphate buffer, 0.2% gelatin.|
|Recognizes the ∽350kDa ATM protein in Daudi and HeLa cells.|
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