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ATOH8 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520710

Catalog No. PIPA520710


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Description

Description

A suggested positive control is A-20 cell lysate. PA5-20710 can be used with blocking peptide PEP-0825.

Basic helix-loop-helix (bHLH) transcription factors play important roles in differentiation processes during embryonic development of vertebrates. ATOH8 (MATH6) is a tissue-restricted member of the atonal superfamily of bHLH transcription factors that exhibits 43-57% identity in the bHLH domain with other mammalian atonal paralogs including the NeuroD and Neurogenin factors. In the mouse, ATOH8 has been implicated in the specification and differentiation of neuronal cell lineages in the brain and may also participate in kidney development. Recent studies show that ATOH8 is a novel component of the pancreatic transcriptional network during embryonic development and suggest a potential role as a modulator of the differentiation program initiated by the pro-endocrine factor Neurog3. It is indispensable for early embryonic development, suggesting a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.
Specifications

Specifications

ATOH8
Polyclonal
Unconjugated
ATOH8
Liquid
ATOH8
A 15 amino acid peptide near the carboxy terminus of human ATOH8.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q96SQ7, Q99NA2
HATH6, bHLHa21; atonal homolog 6; basic helix loop helix transcription factor 6; basic helix-loop-helix transcription factor 6; class A basic helix-loop-helix protein 21; helix-loop-helix protein hATH-6; protein atonal homolog 8
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
500200, 71093, 84913
Documents
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