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MilliporeSigma™ anti-ATP-binding cassette transporter-1, ABCA1 (ABC-1) , Clone: AB.H10, ™ (Chemicon™)
Supplier: MilliporeSigma™ MAB10005/DEL
Description
Mutations in the ABCA1 gene are associated with Tangier disease (TD). TD is an autosomal recessive disorder results from an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and disorders in cellular lipid trafficking. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting
Specifications
ATP-binding cassette transporter-1, ABCA1 (ABC-1) | |
Unconjugated | |
Recombinant fragment, corresponding to amino acids 1800-2260 of Human ABCA1. | |
RUO | |
Primary | |
Semi-purified |
Monoclonal | |
Mouse | |
100 μg | |
Endocrine/Metabolism | |
Chicken, Human, Mouse | |
IgG1 |
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