ATP Synthase β Mouse, Unlabeled, Clone: 10, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 612518
ATP synthase is a large enzyme complex that uses an electrochemical H+ or Na+ gradient to synthesize ATP from ADP and Pi, providing the organism with the ATP needed for energy. The complex consists of two major units, F0 and F1. F0 is embedded in the inner membrane of the mitochondria and, due to its hydrophobic nature, translocates protons across this membrane. F1 is the catalytic portion in the matrix region of the mitochondria and is comprised of α, β, γ, δ, and ε subunits at a 3:3:1:1:1 ratio. The β subunit is synthesized in the nuclear genome,transported to the mitochondria, and assembled with the other subunits. It is encoded by a single copy gene, is ubiquitously expressed and highly conserved among species. ATP synthase β contains an Ets domain binding site, which is a main site for promoter activity. Ets proteins contain domains that are involved in transcriptional activation, protein-protein interactions, and intramolecular repression of DNA binding. This site acts as a target for transcriptional control by the Ets family of transcription factors. Thus, ATP synthase β is involved in the synthesis of ATP and is controlled in part by ETS family proteins.
Bioimaging, Immunofluorescence, Western Blotting
|ATP Synthase β|
|Human ATP Synthase β aa. 428-539|
|Canine, Chicken, Human, Murine, Rat|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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