ATP Synthase α Mouse, Unlabeled, Clone: 51, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 612517

Catalog No. BDB612517

Description

ATP synthase is a large enzyme complex that uses an electrochemical H+ or Na+ gradient to synthesize ATP from ADP and Pi, providing the organism with the ATP needed for energy. The complex consists of two major units, F0 and F1. F0 is embedded in the inner membrane of the mitochondria and, due to its hydrophobic nature, translocates protons across this membrane. F1 is the catalytic portion in the matrix region of the mitochondria and is comprised of α, β, γ, δ, and ε subunits at a 3:3:1:1:1 ratio. The α subunit is a ubiquitous protein that is highly conserved among species. It has an adenine specific binding site that binds both ATP and ADP. There are two glycine rich regions in the sequence, the A domain and B domain, that are thought to be part of the nucleotide binding domain. It has been demonstrated that the N-terminus of the α subunit is necessary for the correct functional and structural connection of F0 to F1. Thus, the α subunit is an essential component of the ATP synthase complex and plays a role in properly orienting the F0 and F1 units.

Immunofluorescence, Western Blotting

Specifications

• Antigen: ATP Synthase α
• Classification: Monoclonal
• Concentration: 250μg/mL
• Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
• Immunogen: Human ATP Synthase α aa. 113-220
• Quantity: 150 μg
• Research Discipline: Cell Biology
• Target Species: Canine, Chicken, Human, Mouse, Rat
• Isotype: IgG2a

• Applications: Western Blot
• Clone: 51
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at -20°C.

For Research Use Only.