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ATP Synthase beta Mouse anti-Bovine, C. elegans, Human, Mouse, Non-human primate, Rat, Clone: 3D5AB1, Invitrogen™ Non-distribution product as customer accommodation. Available on GSA/VA Contract for Federal Government customers only.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen A21351

Catalog No. A21351


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Description

Description

The antibody was produced in vitro using hybridomas grown in serum-free medium, and then purified by biochemical fractionation. Near homogeneity was judged by SDS-PAGE. The epitope recognized by the anti-ATP synthase beta 3D5AB1 is in the region containing the active site of the beta-subunit and is centered approximately at amino acid residue 83. The complete amino acid sequence of the epitope is not known. See Chi SL, Wahl ML, Ke DJ et al. (2007) Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase. Cancer Res 67:4716-4724.

Complex V, also called F1F0ATPase or ATP synthase, is responsible for ATP production in oxidative phosphorylation and can work in reverse as a proton pumping ATPase. This reaction is accomplished by a flux of protons across the membrane as a result of electron transfer. The enzyme was thought to be localized exclusively to mitochondria. However, it has recently been identified on the plasma membrane of several cell types including hepatocytes where it functions as the HDL receptor, on endothelial cells where it may act as the angiostatin receptor, and on the surface of cancer cells. The ATP synthase protein has two main sections: the F1 ATP-ase (soluble) and the F0 ATP-ase (membrane-embedded). The F1 section consists of the alpha, beta, gamma, delta, and epsilon subunits. While the F0 consists of a, b, and c subunits. ATP synthase is extremely conserved through evolution and can be found in plants, fungi, bacteria, and animals. The enzyme in mammals is composed of 17 subunits, five of which make up the easily detached F1. The remainder subunits are components of two stalk domains and the proton pumping F0 part of the machinery. Two of the subunits of the F0 part are encoded on mitochondrial DNA while the other subunits are nuclear encoded. Mutations in the mitochondrial-encoded subunits of ATP synthase (Complex V) cause OXPHOS disease.

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Specifications

Specifications

ATP Synthase beta
Monoclonal
1 mg/mL
HEPES buffered saline with 0.02% sodium azide
P00829, P06576, P56480, P10719
ATPMB, ATPSB, MGC5231
Mouse
IgG1, kappa
100 μg
4° C
Primary
11947, 171374, 327675, 506
Immunocytochemistry, Immunofluorescence, Western Blot
3D5AB1
Unconjugated
ATP5B
Liquid
ATP5B
Human Heart Mitochondria.
Purified
RUO
Antibody
Monoclonal
Bovine, C. elegans, Human, Mouse, Non-human primate, Rat
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