ATP11A Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520995
A suggested positive control is K562 cell lysate. PA5-20995 can be used with blocking peptide PEP-1109.ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.
|A 19 amino acid peptide near the amino terminus of human ATP11A.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|RP11-120K24.1, ATPIH, ATPIS; phospholipid-translocating ATPase; potential phospholipid-transporting ATPase IH; probable phospholipid-transporting ATPase IH|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|23250, 306600, 50770|
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