hnRNP D Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA527534
PA5-27534 targets AUF1 in WB applications and shows reactivity with Human and mouse samples. The PA5-27534 immunogen is recombit fragment corresponding to a region within amino acids 138 and 355 of Human AUF1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.
|Recombit fragment corresponding to a region within amino acids 138 and 355 of Human AUF1|
|Antigen affinity chromatography|
|PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7|
|AUF1, AUF1A, HNRPD, P37, hnRNPD0, ARE-binding protein AUFI, type A, heterogeneous nuclear ribonucleoprotein D0, hnRNP D0|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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