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AVEN Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520288

Catalog No. PIPA520288


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Description

Description

Despite its predicted molecular weight, Aven often migrates at 55kDa in SDS-PAGE. A suggested positive control is Raji cell lysate. PA5-20288 can be used with blocking peptide PEP-0406.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
Specifications

Specifications

Aven
Polyclonal
PBS with 0.02% sodium azide
Q9NQS1, Q9D9K3
PDCD12; cell death regulator Aven; programmed cell death 12
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
311299, 57099, 74268
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Unconjugated
AVEN
Liquid
AVEN
An 18 amino acid peptide from near the amino terminus of human Aven.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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