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anti-Axin-1 Oligoclonal, Invitrogen™

Axin-1Oligoclonal antibody 710204 from Thermo Scientific™ Pierce™ specifically detects Axin-1 in Human samples, and it is validated for WB

Manufacturer:  Invitrogen 710204

Encompass

Catalog No. 71-020-4


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Description

Description

The Axin (Axis Inhibition) protein is a ∼120 kDa negative regulator of Wnt pathway signaling which is involved in regulation of embryonic axis development in vertebrates. In vertebrates, Wnt signaling occurs when the frizzled receptor transduces a signal to the Dishevelled protein, triggering glycogen synthase kinase-3 (GSK-3) inactivation and the accumulation of beta-catenin. Axin binds directly to GSK-3 beta, beta-catenin, and the adenomatous polyposis coli (APC) tumor suppressor protein at separate binding sites; these four proteins form a tetrameric complex that regulates beta-catenin stability and signaling. In addition to its role in Wnt signaling, Axin has been implicated in tumorigenesis, particularly via its interaction with APC. Axin is ubiquitously expressed in almost all tissues, from early development to adulthood. Studies of mutant Axin protein have demonstrated that the phosphorylated form of Axin is more stable than the unphosphorylated form. Other signal transduction pathways in which Axin is involved are the JNK mitogen-associated protein kinase cascade, wherein Axin functions as a scaffold for JNK activation and the TGF- beta signaling pathway, in which Axin acts as an adapter protein for SMAD3, enhancing the transcriptional activity of TGF- beta.

710204 detects Axin-1 in Human samples. 710204 has been successfully used in WB procedures. The immunogen for 710204 is peptide corresponding to amino acids 319-332 of human Axis Inhibitor Protein 1.

Applications:

Western Blotting

Specifications

Specifications

Axin-1
Unconjugated
O15169
Rabbit
IgG
Store at 2 to 8°C for up to 1 month. For long term storage, store at -20°C.
Polyclonal
Human
11HCLC
100μg of Protein A antibody in PBS with 0.09% sodium azide;
Purified
Peptide corresponding to amino acids 319-332 of human Axis Inhibitor Protein 1
Protein A
Primary
8312
SDS
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