AXIN1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521042
A suggested positive control is SK-N-SH cell lysate. PA5-21042 can be used with blocking peptide PEP-1156.AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.
|A 14 amino acid peptide near the carboxy terminus of human AXIN1.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|O15169, O35625, O70239|
|LA16c-314G4.3, AXIN, PPP1R49; axin-1; axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; protein phosphatase 1, regulatory subunit 49|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|12005, 79257, 8312|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok