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AXIN2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA525331

Catalog No. PIPA525331


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology.

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of maligcies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Specifications

Specifications

AXIN2
Polyclonal
Unconjugated
AXIN2
Liquid
AXIN2
KLH conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of human AXIN2
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
O88566, Q9Y2T1
AXIL, axin-2, axin-like protein, axis inhibition protein 2, conductin
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
12006, 8313
Documents
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