B-Raf Mouse, Unlabeled, Clone: 13, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 612375
The Raf kinase family, A-Raf, B-Raf, and C-Raf, act as downstream effectors for Ras. These ser/thr kinases have homologous kinase domains referred to as conserved regions (CR1, CR2, and CR3). Rafs have a critical role in the response to many growth factors including: EGF, PDGF, insulin, IL-2, IL-3, CSF-1, and GM-CSF. Raf can directly interact with Ras-GTP and subsequently become activated. This leads to Raf activation of the MAP kinase pathway by phosphorylating and activating MEK, which then phosphorylates and activates MAP kinaes (ERK).
A-Raf is a proto-onocogene that is highly expressed in urogenital and kidney tissues while B-Raf is expressed at high levels in cerebrum and testes. C-Raf appears to be uniformly and ubiquitously expressed. Cell transformation by A-Raf has been shown to be independent of p21ras, suggesting the possibility of an independent signal transduction pathway. B-Raf is expressed as multiple isoforms that range from 69-72kDa and 79-99kDa. In hematopoietic cells, B-Raf is activated by EPO, GM-CSF, and SCF. Thus, the Raf kinases are important Ras effectors involved in growth factor signaling in a wide variety of cells and tissues.
|Human B-Raf aa. 285-406|
|Human, Murine, Rat|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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