CD273 (B7-DC) Mouse anti-Human, Clone: 176611, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523887
In direct ELISAs, no cross-reactivity with recombit mouse PD-L2, recombit human (rh) B7-1, rhB7-2, rhB7-H1, rhB7-H2, or rhB7-H3 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PDL-2 can act to stimulate an immunogenic response through and alternative receptor from PD-1. At least three isoforms of PDL-2 are known to exist, this antibody is specific to the largest isoform. PDL-2 antibody has no cross-reactivity to PDL-2.
|PBS with 5% trehalose and No Preservative|
|PD-L2, B7DC, Btdc, PDCD1L2, PDL2, bA574F11.2, B7 dendritic cell molecule, B7-DC, PD-1 ligand 2, PD-1-ligand 2, PDCD1 ligand 2, butyrophilin B7-DC, programmed death ligand 2|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|Mouse myeloma cell line NS0-derived recombit human PD-L2/B7-DC Leu20-Pro219 (predicted)|
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