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BACE1 Goat anti-Human, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA120215

Catalog No. PA120215


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Description

Description

PA1-20215 detects beta-Secretase 1 in human, mouse, and rat samples. PA1-20215 has been successfully used in immunohistochemistry (paraffin) procedures. The PA1-20215 immunogen is a synthetic peptide: CLRQQHDDFADDISLLK, corresponding to amino acids 458-501 of Human BACE. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer ft.s disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remt. This remt is then processed by another protease termed gamma-secretase.
Specifications

Specifications

BACE1
Polyclonal
whole serum with 0.09% sodium azide
P56817, P56818, P56819
Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1
Goat
IgG
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
Unconjugated
BACE1
Liquid
BACE1
Synthetic peptide: CLRQQHDDFADDISLLK, corresponding to amino acids 458-501 of Human BACE
50 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
23621, 23821, 29392
Documents
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