Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

BACE1 Goat anti-Human, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA120215

Catalog No. PA120215

Add to cart



PA1-20215 detects beta-Secretase 1 in human, mouse, and rat samples. PA1-20215 has been successfully used in immunohistochemistry (paraffin) procedures. The PA1-20215 immunogen is a synthetic peptide: CLRQQHDDFADDISLLK, corresponding to amino acids 458-501 of Human BACE. Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.

Amyloid beta peptide is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer ft.s disease. This peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease termed beta-secretase (BACE), of which there are two isoforms, BACE1 and 2. This enzyme is synthesized as a propeptide that must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP and a membrane-bound remt. This remt is then processed by another protease termed gamma-secretase.


whole serum with 0.09% sodium azide
P56817, P56818, P56819
Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1
Immunohistochemistry (Paraffin)
Synthetic peptide: CLRQQHDDFADDISLLK, corresponding to amino acids 458-501 of Human BACE
50 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
23621, 23821, 29392
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit