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BACE1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112529

Catalog No. 01-674-189


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Description

Description

Accumulation of the amyloid-b (Ab) plaque in the cerebral cortex is a critical event in the pathogenesis Alzheimer's disease. Ab peptide is generated by proteolytic cleavage of the b-amyloid protein precursor(APP) at b- and g-sites by two proteases. APP is first cleaved by b-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for g-secretase to generate the 4kDa amyloid-b peptide, which is deposited in the brains of all sufferers of Alzheimer's disease. The long-sought b-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). bACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.

In Western blot, this antibody detects a ~70kDa band in human brain lysate.
Specifications

Specifications

BACE1
Polyclonal
Unconjugated
BACE1
Liquid
BACE1
Synthetic peptide corresponding to residues 485-501 of human BACE.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P56817, P56818
beta Secretase 1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
23621, 23821
Documents
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