BACE2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1754
PA1-754 detects human and mouse beta-secretase 2 (BACE2) from transfected cells. This product has recently been remanufactured in new rabbits as Cat. No. PA1-1754. PA1-754 has been successfully used in Western blot and ICC/IF procedures. By Western blot this antibody detects an ~58 kDa protein representing BACE2 from SY-SY5Y cells overexpressing the human gene. The PA1-754 immunogen is amino acid residues 503-518 from human BACE2. This sequence is completely conserved in mouse. The PA1-754 immunizing peptide (Cat. No. PEP-167) is available for use in neutralization and control experiments.BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
|Synthetic Peptide: C P(503) E V V N D E S S L V R H R W K(518)|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|BACE2, Beta-Site APP-Cleaving Enzyme 2, Aspartyl protease 1, Asp 1, ASP1, Membrane-associated aspartic protease 1, Memapsin-1, Down region aspartic pr|
|-20° C, Avoid Freeze/Thaw Cycles|
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