BACE2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112530
In Western blot, this antibody detects a ∽70 kDa band in human heart tissue lysate.BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
|Synthetic peptide corresponding to residues 44-59 of human BACE2.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 0.02% sodium azide|
|Q9Y5Z0, Q9JL18, Q6IE75|
|BACE2, AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP, beta secretase 2|
|-20° C, Avoid Freeze/Thaw Cycles|
|25825, 288227, 56175|
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