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BACE2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112531

Catalog No. 01-674-191


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Description

Description

A suggested positive control for this product is human heart tissue lysate.

BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients.
Specifications

Specifications

BACE2
Polyclonal
PBS with 0.02% sodium azide
Q9Y5Z0
BACE2, AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP, beta secretase 2
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
25825
Western Blot
Unconjugated
BACE2
Liquid
BACE2
Synthetic peptide corresponding to residues 496-511 of human BACE2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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